Cell Polarity and Dynamics Lab

We study how cell polarity controls the dynamic processes that drive tissue development, homeostasis, and regeneration. We dive deep into fundamental principles of polarity that integrate signaling pathways with organelle positioning. By harnessing this knowledge, we aim to engineer cells to guide development and combat disease.

Currently, we combine micropatterned cell system with organoid and mouse models to investigate a novel form of structural polarity, which we term ER–PM contacts–dependent polarity. This polarity provides a fundamental mechanism for how cells decide when and where to move, and may offer new insights into neurobiology, immunology, and developmental biology. Using quantitative imaging, synthetic biology, omics-based screening, and genetic perturbation tools, we are uncovering both the molecular basis and in vivo roles of this newly recognized polarity program.